Homer Simpson Live

During a live broadcast segment – recorded twice for west and east coast viewers of the show – voice actor Dan Castellaneta was situated in an isolated sound booth at the Fox Sports facility listening and responding to callers while The Simpsons producer and director David Silverman operated keyboard-triggered animations with a custom keypad device that included printed animated Homer thumbnail icons. Realtime lip sync and animations were created with Adobe Character Animator. Adobe also implemented a way to send the Character Animator output directly as a video signal via SDI and enable the live broadcast.

Full article on ToonBrew:
http://www.cartoonbrew.com/tech/simpsons-used-adobe-character-animator-create-live-episode-139775.html